PReS-FINAL-2162: Development of a risk model to predict methotrexate intolerance in juvenile idiopathic arthritis
نویسندگان
چکیده
Methods In a large, prospective JIA cohort, potential predictors (clinical variables and single nucleotide polymorphisms) were determined at the time of MTX start. The Methotrexate Intolerance Severity Score was employed to measure MTX intolerance in the first year of treatment. MTX intolerance was most prevalent at 6 or 12 months after MTX start. This was defined as the outcome for the prediction model. The model was developed in 152 patients using multivariate logistic regression analysis. It was subsequently internally validated using bootstrapping.
منابع مشابه
PReS-FINAL-2165: Pharmacogenetic determinants of response to methotrexate in juvenile idiopathic arthritis
Introduction Juvenile idiopathic arthritis (JIA) is the most common arthritis disease of childhood and is an important cause of disability. Methotrexate (MTX) is the mainstay treatment in JIA. Unfortunately, 30-35% of patients fail to respond MTX, and the delay in identifying the optimal treatment at an early stage of disease can lead to longterm joint damage. Recent studies have evaluated comp...
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عنوان ژورنال:
دوره 11 شماره
صفحات -
تاریخ انتشار 2013